The stud piercing that some people get right above their lip.  I can't talk to them without thinking "Hey, you got some shit on your face."  ::makes wiping face motion::  Don't get me wrong, I'm all for piercings, but that's really distracting. 

The hipster staff of damn near every record store.  Some of them are cool if you can attain "regular" status, but up until then, they seem to look at every choice I make with absolute derision.

Vegetarians/Vegans who pimp it all the time.

Cell phones with annoyingly catchy song ringtones.  I've been singing Return of the Mack all day because of this, and I'm about to put a drill to my temple.

And when I sneeze five times in a row (it's allergy season), I don't need five individual "bless you"s, which I then have to say thank you for.  Two will suffice, after that it should be assumed.

I saw something above about pop up ads, and I thought of something similarly annoying.  Flyers on my car.  "Loose up to 300lbs using herbal blah blah blah!  I tried it, and it works!" or "Work from home using this obvious pyramid scheme!".  How does this advertising campaign work?  And worse yet, I get religious flyers on my car pretty often.  If you're choosing a faith based on something stuck to your windshield...  Well, good luck with that I guess.

And bloggers/writers who end a declarative sentence with an ellipsis.  Are all of your thoughts unfinished?  How about don't write them until they are.

And women, please, don't tattoo your boobs.  They don't need drawings on them to keep me entertained.